In the precision manufacturing process of active pharmaceutical ingredients (API), efficient extraction and separation of reaction mixtures are the core links that determine product purity, yield and cost. With the increasingly stringent global drug regulation and the deepening of the concept of green pharmaceutical manufacturing, traditional intermittent extraction processes face severe challenges in terms of efficiency, solvent consumption, and environmental compliance. Continuous, automated, and low-solvent consumption liquid-liquid extraction technology has become an inevitable choice for the upgrading of the pharmaceutical industry.

Traditional intermittent extraction has significant bottlenecks
1.Low efficiency: slow mass transfer rate, many stages, and large equipment footprint.
2.High solvent consumption: large entrainment losses and high subsequent recovery costs.
3.Batch-to-batch differences: operation depends on experience, and stability and reproducibility are difficult to guarantee.
4.Safety and environmental pressure: open operation increases the risk of VOCs escape, and the organic content in wastewater is high, making it difficult to treat.

Centrifugal Extraction Continuous Extraction Technology

Continuous countercurrent centrifugal extraction technology, with its unique advantages, is becoming the mainstream direction of API extraction process upgrade. The working principle of its core equipment, the centrifugal extractor, is as follows:
1.Efficient mixing: The two-phase liquid is mixed instantly with high shear in a high-speed rotating drum through a specially designed mixing device, which greatly increases the mass transfer specific surface area.
2.Rapid separation: Under the action of a strong centrifugal field, the mixed liquid can achieve rapid and thorough phase separation in seconds based on density difference, effectively avoiding droplet aggregation and entrainment.
3.Continuous countercurrent operation: Multi-stage series connection realizes true continuous countercurrent contact, significantly improves the driving force of mass transfer, and achieves higher extraction efficiency with fewer stages.

The Core Advantages of Centrifugal Extractor in API Reaction Solution Extraction

Compared with traditional technology, centrifugal extractor brings revolutionary improvement to pharmaceutical companies
1.Mass transfer efficiency is increased by 30%-50%, significantly reducing the number of theoretical stages and equipment volume.
2.Continuous automatic operation reduces manual intervention and improves production capacity and site utilization.
3.Solvent entrainment loss is extremely low, significantly reducing solvent procurement and recovery costs.
4.The closed design eliminates solvent volatilization, ensures operator safety, and meets strict GMP/EHS regulations.
5.High separation factor ensures thorough phase separation, reduces the burden of subsequent processing, and improves the purity of API products (solvent residue can be controlled to ≤50ppm).
6.Significantly reduce solvent consumption per unit product and wastewater generation.
7.The content of residual organic matter in wastewater is greatly reduced, reducing the difficulty and cost of subsequent sewage treatment.

Driven by the triple forces of quality, efficiency and sustainability, the use of advanced continuous centrifugal extraction technology to efficiently separate API reaction solutions has become a consensus among the world's leading pharmaceutical companies. With a deep understanding of pharmaceutical processes and continuous innovation, Zhengzhou Tiei Extraction is committed to providing the industry with high-performance, high-reliability centrifugal extraction solutions, helping pharmaceutical companies break through extraction bottlenecks, optimize production processes, reduce overall costs, enhance core competitiveness.
Email: sales@tieiextraction.com
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