In the synthesis of pharmaceutical intermediates and the purification of active pharmaceutical ingredients (APIs), n-butanol is widely used as an extraction solvent. However, during liquid–liquid extraction and separation from the aqueous mother liquor, three major technical challenges are commonly encountered: low phase separation efficiency leading to solvent entrainment and losses, batch operation modes that limit continuous production, and safety risks associated with highly volatile solvents. The introduction of the CWL-M series centrifugal extractor by Zhengzhou Tiei Extraction is delivering a revolutionary solution to the fine chemicals industry through advanced extraction technology.
Achieving 98% Purification Efficiency through Three-Stage Countercurrent Extraction Technology
The CWL-M series centrifugal extractor utilizes the countercurrent extraction principle, achieving continuous countercurrent contact between the extractant and the feed liquid in a closed system under the action of high-speed centrifugal force. Experimental data shows that for the n-butanol extraction system of phenolic pharmaceutical intermediates, a single unit can achieve an extraction efficiency of 98%, reducing solvent loss by 40% compared to traditional extraction equipment, and increasing the recovery rate of the active ingredient to 99.5%.
Due to the flammable and explosive nature of n-butanol, the CWL-M series centrifugal extractor is equipped with a nitrogen sealing system and an anti-static coating, allowing for precise control of the oxygen content inside the equipment to below 5%. The modular quick-release structure reduces cleaning and maintenance time by 60%, and the special material of the drum components ensures resistance to highly corrosive environments. This ATEX explosion-proof certified equipment is already operating stably in more than 20 pharmaceutical raw material manufacturers in China.
Case Study: A Pharmaceutical Company
In a vitamin E acetate purification project, the CWL-M-50 centrifugal extractor successfully reduced the number of extraction stages from 6 in the traditional process to 3, shortening the extraction time by 70%, increasing the solvent recycling rate to 92%, and significantly reducing the cost of n-butanol.
As a national-level specialized and innovative "little giant" enterprise in China, Zhengzhou Tiei Extraction boasts the largest centrifugal extractor testing center in Asia and holds over 30 core patented technologies. Its centrifugal extractor has set industry standards in the n-butanol extraction process for star products such as cephalosporin antibiotics and paclitaxel.
Email: sales@tieiextraction.com
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