In the modern pharmaceutical and fine chemical industries, efficient, continuous, and automated separation and purification technologies have become crucial for enhancing core competitiveness. Regarding the selection of extraction equipment, centrifugal extraction process, with its advantages of high extraction efficiency, enclosed process, low solvent loss, ease of automation integration, and superior space utilization, is gradually replacing traditional gravity settlers and stirred-tank extraction equipment, becoming the mainstream process solution for continuous solvent extraction.
Based on the mode of contact and flow behavior between the extractant and the feed, centrifugal extraction process is generally classified into two core operational modes: cross current extraction and countercurrent extraction. Among these, countercurrent extraction is particularly advantageous in separation processes requiring high recovery and high purity, as it enables stepwise utilization of the extractant, provides a large mass transfer driving force, and minimizes specific solvent consumption. Typical applications include the extraction and purification of colistin, penicillin, tocopherols, active components of Ginkgo biloba (flavonoids and terpene lactones), tea polyphenols, as well as other natural products and synthetic pharmaceuticals.
The CWL-M series centrifugal extractor independently developed by Zhengzhou Tiei Extraction Technology Co., Ltd. is high-efficiency equipment specifically designed to meet the requirements of modern continuous production. This series can be flexibly configured for both cross current and countercurrent extraction modes and delivers performance advantages over conventional equipment in several key aspects:
1.Flexible and efficient operation: Supports both batch and continuous processing. Mixing and phase separation are completed within seconds, with low stage holdup, significantly improving production throughput and material utilization.
2.Energy-efficient with high throughput: Provides substantially higher processing capacity per unit of energy consumption compared with traditional equipment, making it well suited for large-scale continuous production.
3.Corrosion-resistant construction: Wetted parts are manufactured from specialty materials such as perfluoropolymers, offering excellent resistance to strongly corrosive media including hydrochloric acid and mixed acids, thereby extending equipment service life.
4.Strong resistance to emulsification: Multiple mixer structure configurations are available to effectively handle emulsification-prone systems and ensure stable and reliable phase separation performance.
With its unique technical features combining high-intensity mixing and high-speed centrifugal separation, the CWL-M centrifugal extractor is not only suitable for the main extraction process but is also gradually replacing traditional stirred tanks and settling tanks in refining stages such as washing, desalting, and impurity removal of active pharmaceutical ingredients. This is driving the upgrade of production towards a fully enclosed, fully automated, and continuous green manufacturing model.
Currently, liquid-liquid extraction equipment centrifugal extractor and related processes have been successfully implemented in several well-known pharmaceutical companies and fine chemical projects in China, effectively helping companies improve product purity, reduce solvent consumption, and optimize the production environment. Zhengzhou Tiei Extraction provides comprehensive technical support from process development and equipment selection to system integration, assisting companies in achieving the modernization of extraction and separation technology.
Email: sales@tieiextraction.com
Whatsapp: +86 19069612820
