Liquid–liquid extraction is the classical method used for herbicide isolation, especially from water and biological fluid samples. Ethyl acetate, dichloromethane, and their mixtures are among the preferred extraction solvents for phenylureas, triazoles, amides, carbamates, benzimidazoles, and chlorotriazines. The extraction efficiency is modified by adjustment of pH and ionic strength in the aqueous phase. In situ derivatization of the target analytes is also used as an effective tool (e.g., chlorophenoxy acidic herbicides are derivatized with dimethyl sulfate prior to their extraction by n-hexane).

Liquid–liquid extraction is also widely used in the production of fine organic compounds, the processing of perfumes, the production of vegetable oils and biodiesel, and other industries.It is among the most common initial separation techniques.

Zhengzhou Tiei Extraction Technology Co.,Ltd designs, manufactures CWL-M centrifugal extractor
for the liquid/liquid extraction and separation.CWL650-M successfully applied in lactic acid purify from Fermentation , at Asia biggest factory.