During the production of antibiotics, vitamins, chiral pharmaceutical intermediates, alkaloids, and other pharmaceutical products, many active pharmaceutical ingredients (APIs) exhibit heat-sensitive characteristics—they are highly sensitive to temperature, pH value, and processing time. Prolonged exposure to unsuitable conditions can easily lead to deactivation, degradation, or isomerization, directly resulting in reduced product yield, increased impurities, and even the scrapping of entire batches.
Taking penicillin as an example, Penicillin G is unstable under low pH conditions (2.0–2.5). Traditional extraction processes often require several hours to complete, causing significant degradation of active ingredients during processing. This industry challenge has long troubled pharmaceutical manufacturers.
How Can Centrifugal Extractor Solves the Problem of Heat-Sensitive Pharmaceutical Degradation?
The core answer lies in the extremely short contact time between the two phases. The CWL-M Centrifugal Extractor developed by Zhengzhou Tiei Extraction utilizes high-speed rotation to generate a powerful centrifugal force field, enabling the aqueous phase and organic phase to complete mixing, mass transfer, and rapid separation within seconds. This compresses the residence time from tens of minutes or even hours in traditional extraction equipment to just seconds.
Taking Penicillin G Extraction as an Example:
In conventional processes, Penicillin G is highly susceptible to hydrolysis during butyl acetate extraction at pH 2. After adopting a multistage counter-current centrifugal extraction process, the extraction time was reduced from 2 hours to 10 minutes, while the hydrolysis loss rate decreased from 15% to below 2%. Further studies have shown that, through proper pH control combined with centrifugal extraction, the loss of Penicillin G can be controlled to below 1%.
Core Technical Advantages of the CWL-M Centrifugal Extractor
1.Second-Level Separation for Maximum Protection of Active Ingredients
The equipment operates under a centrifugal force field of 800–1200 G, with a two-phase contact time of only a few seconds. Compared with traditional gravity settling, which requires tens of minutes for phase separation, the residence time is reduced by more than 90%, effectively preventing the degradation of heat-sensitive substances caused by prolonged contact. This feature is particularly critical for pharmaceutical ingredients that are highly time-sensitive, such as antibiotics, vitamins, and enzyme preparations.
2.Fully Enclosed Operation to Prevent Oxidation and Contamination
The equipment adopts a fully sealed structure, eliminating air oxidation and external contamination. It is particularly suitable for extracting oxidation-sensitive pharmaceutical components. The closed system also meets GMP clean production requirements and prevents VOC emissions.
3.Ambient Temperature Operation Without Heating
Centrifugal extraction relies on physical separation principles and achieves efficient mass transfer without heating. For heat-sensitive pharmaceuticals, this means the entire extraction process can be completed at ambient temperature, fundamentally avoiding the degradation of active ingredients caused by high temperatures.
4.Continuous Automation with High Batch Consistency
The equipment can achieve continuous automatic operation, replacing traditional batch processing. Each batch of material undergoes identical extraction conditions, effectively ensuring uniform and stable API quality between batches and fully complying with pharmaceutical quality control standards.
Industry Applications
Erythromycin Extraction: After adopting the centrifugal extractor, the extraction yield increased from 92% in traditional processes to 98.5%. The single-stage separation time is less than 30 seconds, effectively minimizing activity loss.
Cephalosporin C Extraction: After three-stage counter-current extraction, the purity reached 99.6%, representing a 15% improvement compared with traditional processes.
Azithromycin Production: After adopting a three-stage counter-current centrifugal extraction process, the overall extraction rate exceeded 99%.
Zhengzhou Tiei Extraction CWL-M Series Centrifugal Extractor is specifically designed for the extraction of heat-sensitive pharmaceuticals. With its three core technologies—second-level separation, ambient-temperature operation, and fully enclosed processing—it helps pharmaceutical manufacturers fundamentally solve the problem of active ingredient degradation and achieve large-scale production with high yield, high purity, and high product quality.
Email: sales@tieiextraction.com
Whatsapp: +86 19069612820
